Services
Preclinical
RSS can provide design and manage your drug development program from Discovery to Phase I. We have managed and or Study Directed studies of the following types:
IND enabling Toxicity up to 12 months
Safety Pharmacology (Cardiovascular, Respiratory, and CNS)
Infusion Delivery
Inhalation Delivery
Gene Therapy with Intravenous and Direct Deposition (intraparenchymal, intrathecal, intracerebroventricular)
Regulatory
RSS can write, review, or audit the preclinical sections of your regulatory documents and assist with communications with US and and EU regulatory bodies.
Data Analysis
RSS can derive data either from digital waveform recordings or paper tracings and provide data summarization and descriptive statistics. RSS is proficient with data aquisition systems (Pohnemah, EMKA, Notocord) and can also do some a basic statistical analyses (SigmaPlot, GraphPad)
Laboratory Animal Medicine and Surgery
RSS is also highly experienced in laboratory animal medicine and the Director has served as Attending Veterinarian at several pharmaceutical companies and in academia. RSS can provide surgical guidance in vascular access ports/buttons, telemetry data collection, various vascular modifications, in vivo tissue sample collections, and vivarium management
Our Scientific Journey
About Us
Rook Scientific Services is a consulting firm providing specialized scientific solutions across various preclinical study designs and drug development packages.
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The principal consultant for RSS is Michael Stonerook, PhD (physiology), DVM, DABT. He has participated in many roles during my career including Attending Veterinarian, surgical veterinarian, study director for pharmaceutical safety pharmacology studies and general toxicology studies (GLP and non-GLP), production of IND packages, and manager/director of research groups. His research experience includes the direction and evaluation of cardiovascular safety studies, respiratory safety studies, inhalation delivery studies, and intravenous infusion studies (ambulatory and non-ambulatory in multiple species). Additionally, he has had roles in the development and testing of equipment, software, and animal models currently in use in preclinical studies throughout the industry.